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AVANÇOS NO DIAGNÓSTICO E TRATAMENTO DAS DISFONIAS: Trajetória de uma Equipe de Sucesso Internacional - Dra Diane Bless
Objetivos Discutir os avanços no diagnóstico e tratamento das disfonias: Trajetória de uma equipe de sucesso Internacional
Programa Tópicos do Simpósio:
1. Três décadas de evolução do exame de laringe: uma imagem vale mais que mil palavras
2. A evolução do tratamento das cicatrizes de prega vocal: como estamos vencendo essa batalha
3. Terapia de voz intensiva: uma base racional de tratamento
4. Abordagem comportamental e cirúrgica das disfonias, da infancia à senescência
5. Entrevista com Diane Bless: a evolução de uma trajetória de trabalho em equipe
Coordenação: Dra Mara Behlau
Carga horária 9h às 18h
Público Alvo Fonoaudiólogos, estudantes de fonoaudiologia e pósgraduação e áreas relacionadas
Temário Simpósio Internacional do CEV
Informações gerais BIOGRAPHICAL SKETCH - DIANE M. BLESS - PROFESSOR EMERITUS
San Diego State University, San Diego, CA B.A. 1964 Speech Pathology/Audiology
University of Redlands, Redlands, CA M.S. 1965 Speech and Hearing Science
University of Redlands, Redlands, CA Ph.D. 1971 Communicative Disorders
A. Positions and Honors.
1965-1965 Teaching Assistant, Department of Speech Pathology & Audiology, University of Redlands, Redlands, CA
1964-1965 Speech Therapist, Orange County Crippled Children's Society, Orange, CA
1965-1969 Research and Teaching Assistant, Depart of Communicative Disorders, University of Wisconsin, Madison, WI
1969-1970 Assistant Professor, Dept. Speech, Div. Speech Science, University of Washington, Seattle, WA
1971-1972 Postdoctoral Fellow and Research Associate, Depart of Communicative, University of Wisconsin, Madison, WI
1972-1973 Lecturer, Department of Communicative Disorders, University of Wisconsin, Madison, WI
1973-1974 Speech Consultant, Deaf Treatment Center, Mendota Mental Health Institute, Madison, WI
1974-1976 Clinical Supervisor, Department of Communicative Disorders, University of Wisconsin, Madison, WI
1976-1980 Assistant Professor, Department of Communicative Disorders, University of Wisconsin, Madison, WI
1980-1982 Associate Professor, Department of Communicative Disorders, University of Wisconsin, Madison, WI
1987-2006 Professor, Departments of Communicative Disorders and Surgery, University of Wisconsin, Madison, WI
2006-pres Professor Emeritus, Depart. of Communicative Disorders and Surgery, University of Wisconsin, Madison, WI
Selected Summary of Honors and Awards 2000-2010
Research Poster Awards, 1st and 2nd place, American Bronchoesophagological Association and American Laryngological Association, Orlando, 2000; Research Poster Award, 2nd place, American Bronchoesophagological Association 2001; Resident Award Triological meeting, 2001; David E Brewer award for Best Scientific Poster, Voice Foundation Meeting, 2002; Research Poster Award, 1st place, American Bronchoesophagological Association, 2002; Honors of the American Speech-Language Hearing Association. Highest honor bestowed by the Association for outstanding clinical, academic, and professional service. November 2003; Research Poster Awards, 1st and 3rd places, American Broncho-Esophagological Association, 2004; Broyles-Maloney Thesis Award, American Broncho-Esophagological Association, 2005; Wisconsin Speech-Language Pathology and Audiology Association; 2005 Nominee for ASHA's Frank R. Kleffner Lifetime Clinical Career Award" for outstanding contributions to clinical science and practice in communication science and disorders over the past twenty years;" Honorable Mention of the Casselberry Award 2006, “The Roles of Vitamin A in Maintaining Vocal Folds”; David G. Brewer Award for best scientific poster at the 2007 Voice Foundation Meeting; Research Poster Award, 1st place, American Laryngological Association, Orlando, 2008; Research Poster Award, 2nd place, American Broncho-Esophagological Association, Orlando, 2008. ASHA Foundation Frank R. Kleffner Lifetime Clinical Career Award" for outstanding contributions to clinical science and practice in communication science and disorders over the past twenty years;University of Wisconsin Department of Surgery Division of Otolaryngology Diane M. Bless Endowed Chair established 2010; American Laryngological Association James E. Newcomb Award for outstanding contributions and accomplishments in the field of Laryngology and Rhinology.
Selected peer-reviewed publications (in chronological order).
1. Ford CN, Bless DM, Campos G, Leddy M. Anterior commissure microwebs associated with vocal nodules: detection, prevalence, and significance. Laryngoscope. 1994;104(11 Pt 1):1369-1375.
2. Nakayama M, Ford CN, Brandenburg JH, Bless DM. Sulcus vocalis in laryngeal cancer: a histopathologic study. Laryngoscope. 1994;104(1 Pt 1):16-24.
3. Rodriquez AA, Ford CN, Bless DM, Harmon RL. Electromyographic assessment of spasmodic dysphonia patients prior to botulinum toxin injection. Electromyogr Clin Neurophysiol. 1994;34(7):403-407.
4. Ford CN, Unger JM, Zundel RS, Bless DM. Magnetic resonance imaging (MRI) assessment of vocal fold medialization surgery. Laryngoscope. 1995;105(5 Pt 1):498-504.
5. Ford CN, Staskowski PA, Bless DM. Autologous collagen vocal fold injection: a preliminary clinical study. Laryngoscope. 1995;105(9 Pt 1):944-948.
6. Ford CN, Inagi K, Bless DM, Khidr A, Gilchrist KW. Sulcus vocalis - a rational analytical approach to diagnosis and management. Ann Otol Rhinol Laryngol. 1996;105(3):189-200.
7. Inagi K, Ford CN, Bless DM, Heisey D. Analysis of factors affecting botulinum toxin results in spasmodic dysphonia. J Voice. 1996;10(3):306-313.
8. Inagi K, Ford CN, Rodriquez AA, Schultz E, Bless DM, Heisey DM. Efficacy of repeated botulinum toxin injections as a function of timing. Ann Otol Rhinol Laryngol. 1997;106(12):1012-1019.
9. Inagi K, Khidr AA, Ford CN, Bless DM, Heisey DM. Correlation between vocal functions and glottal measurements in patients with unilateral vocal fold paralysis. Laryngoscope. 1997;107(6):782-791.
10. Roy N, McGrory JJ, Tasko SM, Bless DM, Heisey D, Ford CN. Psychological correlates of functional dysphonia: an investigation using the Minnesota Multiphasic Personality Inventory. J Voice. 1997;11(4):443-451.
11. Ford CN, Roy N, Sandage M, Bless DM. Rigid endoscopy for monitoring indirect vocal fold injection. Laryngoscope. 1998;108(10):1584-1586.
12. Inagi K, Connor NP, Schultz E, Ford CN, Cook CH, Bless DM, Heisey DM. Increased acute and chronic mitotic activity in rat laryngeal muscles after botulinum toxin injection. Laryngoscope. 1998;108(7):1055-1061.
13. Inagi K, Connor NP, Ford CN, Schultz E, Rodriquez AA, Bless DM, Pasic T, Heisey DM. Physiologic assessment of botulinum toxin effects in the rat larynx. Laryngoscope. 1998;108(7):1048-1054.
14. Roy N, Ryker KS, Bless DM. Vocal violence in actors: An investigation into its acoustic consequences and the effects of hygienic laryngeal release training. J Voice. 2000;14(2):215-230.
15. Roy N, Bless DM. Personality traits and psychological factors in voice pathology: A foundation for future research. J Speech Lang Hear Res. 2000;43(3):737-748.
16. Marendic B, Galatsanos NP, and Bless D. A new approach for measuring the motion of vibrating vocal folds”, Proceedings of 5th Workshop on Advances in Quantitative Laryngoscopy, Voice and Speech Research, 2001.
17. Marendic B, Galatsanos NP, and Bless D. A new active contour algorithm to track vibrating vocal folds. To appear in IEEE Proceedings of the International Conference on Image Processing, Thessaloniki, Greece, September 2001.
18. Thibeault SL, Gray SD, Bless DM, Chan RW, Ford CN. Histologic and rheologic characterization of vocal fold scarring. Journal of Voice. 2002;16(1):96-104.
19. Suzuki T, Bless DM, Connor NP, Ford CN, Lee K, Inagi K. Age-related alterations in myosin heavy chain isoforms in rat intrinsic laryngeal muscles. Ann Otol Rhinol Layngol. 2002; 111(11):962-967.
20. Inagi K, Connor NP, Suzuki T, Ford CN, Bless DM, Nakajima M. Glottal configuration, acoustic, and aerodynamic changes induced by variation in suture direction in arytenoid adduction procedures. Ann Otol Rhinol Laryngol 2002;111(10):861-870.
21. Kriesel KJ, Thibeault SL, Chan RW, Suzuki T, VanGroll PJ, Bless DM, Ford CN. Treatment of vocal fold scarring: Rheological and histological measures of homologous collagen matrix. Ann Otol Rhinol Laryngol. 2002;111(10):884-889.
22. Hirano S, Thibeault S, Bless DM, Ford CN, Kanemaru SI. Hepatocyte growth factor and its receptor c-Met in rat and rabbit vocal folds. Ann Otol Rhinol Laryngol. 2002;111(8):661-666.
23. Hirano, S., Bless, D. M., Massey, R. J., Hartig, G. K., and Ford, C. N.: Morphological and functional changes of human vocal fold fibroblasts with hepatocyte growth factor. Ann Otol Rhinol Laryngol 112:1026-1033, 2003.
24. Jiang J, Bless D: Vocal fold stress in voice overuse and abuse, Perspec on Voice and Voice disorders. Vol 13, 2003
25. Rousseau B., Hirano S., Scheidt T.D., Welham N.V., Thibeault S.L., Chan R.W., Bless D.M. Characterization of vocal fold scarring in a canine model. Laryngoscope. 2003; 113: 620-627.
26. Hirano S, Bless DM, Rousseau B, Welham N, Scheidt T, Ford CN. Fibronectin and adhesion molecules on canine scarred vocal folds. Laryngoscope. 2003;113(6):966-972.
27. Hirano S, Bless D.M, Heisey D, Ford CN. Effect of Growth Factors on Hyaluronan Production by Canine Vocal Fold Fibroblasts. Ann Otol Rhinol Laryngol. 2003;112(7):617-624.
28. Thibeault SL, Bless DM, Gray SD. Interstitial protein alterations in rabbit vocal fold with scar. J Voice. 2003;17(3):377-383.
29. Hirano, S, Bless DM, Hartig GK, Massey RJ, Ford CN. Morphological and Functional Changes of Human Vocal Fold Fibroblasts with Hepatocyte Growth Factor. Ann Otol Rhinol Laryngol. 2003; 112:(12) 1026-1033.
30. Hirano S, Bless D, Heisey D, Ford C. Roles of hepatocyte growth factor and transforming growth factor beta 1 in production of extracellular matrix by canine vocal fold fibroblasts. Laryngoscope. 2003;113(1):144-148
31. Welham, N. V., Rousseau, B., Ford, C. N., and Bless, D. M. Tracking outcomes after phonosurgery for sulcus vocalis: A case report. J Voice. 17:571-578, 2003.
32. Rousseau B, Hirano S, Chan RW, Welham NV, Thibeault SL, Ford CN, Bless DM. Characterization of chronic vocal fold scarring in a rabbit model. J Voice 2004; 18:(1) 116-124.
33. Thibeault SL, Rousseau B, Welham NV, Hirano S, Bless DM. Hyaluronan levels in acute vocal fold scar. Laryngoscope 2004; 114:(4) 760-764.
34. Hirano S, Bless DM, Rousseau B, Welham N, Montequin D, Chan RW, Ford CN. Prevention of vocal fold scarring by topical injection of hepatocyte growth factor in a rabbit model. Laryngoscope. 2004;114(3):548-556.
35. Hirano S, Bless DM, Nagai H, Rousseau B, Welham NV, Montequin DW, Ford CN. Growth factor therapy for vocal fold scarring in a canine model. Ann Otol Rhinol Laryngol. 2004;113:(10) 777-785.
36. Rousseau B, Sohn J, Montequin DW, Tateya I, Bless DM. Functional outcomes of reduced hyaluronan in acute vocal fold scar. Ann Otol Rhinol Laryngol. 2004; 113:(10) 767-776.
37. Hirano S, Bless DM, del Rio AM, Connor NP, Ford CN. Therapeutic potential of growth factors for aging voice. Laryngoscope 2004; 114:(12) 2161-2167.
38. Tateya T, Tateya I, Sohn JH, Bless DM. Histologic characterization of rat vocal fold scarring. Ann Otol Rhinol Laryngol. 2005;114:(3) 183-191.
39. Yan Y, Ahmad K, Kunduk M, Bless D. Analysis of Vocal-fold Vibrations from High-Speed Laryngeal Images Using a Hilbert Transform-Based Methodology. J Voice 2005; 19:(2) 161-175.
40. Hirano S, Nagai H, Tateya I, Tateya T, Ford CN, Bless DM. Regeneration of aged vocal folds with basic fibroblast growth factor in a rat model: A preliminary report. Ann Otol Rhinol Laryngol. 2005; 114:(4) 304-308.
41. Berry DA, Reininger H, Alipour F, Bless DA, Ford CN. Influence of Vocal Fold Scarring on Phonation: Predictions from a Finite Element Model. Ann Otol Rhinol Laryngol. 2005;114(11):847-52.
42. Tateya T, Tateya L, Sohn JH, Bless DM. Histological Study of Acute Vocal Fold Injury in a Rat Model. Ann Otol Rhinol Laryngol. 2006;115(4):285-92.
43. Welham NV, Marriott G, Bless DM. Proteomic profiling of rat thyroarytenoid muscle. J Speech Lang Hear Res. 2006; 49:(3) 671-685.
44. Tateya T, Tateya I, Bless DM. Collagen subtypes in human vocal folds. Ann Otol Rhinol Laryngol. 2006; 115:(6) 469-476.
45. Yan Y, Chen X, Bless D. Automatic tracing of vocal-fold motion from high-speed digital images. IEEE Trans Biomed Eng 2006; 53:(7) 1394-1400.
46. Yan Y, Chen X, Bless D. Automatic tracing of vocal-fold motion from high-speed digital images. IEEE Trans Biomed Eng 2006; 53:(7) 1394-1400.
47. Kunduk M, Yan Y, McWhorter AJ, Bless D. Investigation of voice initiation and voice offset characteristics with high-speed digital imaging. Logoped Phoniatr Vocol. 2006;31:(3) 139-144.
48. Lim X, Tateya I, Tateya T, Munoz-Del-Rio A, Bless DM. Immediate inflammatory response and scar formation in wounded vocal folds. Ann Otol Rhinol Laryngol 2006;115:(12) 921-929.
49. Rousseau B, Tateya I, Lim X, Munoz-Del-Rio A, Bless DM. Investigation of anti-hyaluronidase treatment on vocal fold wound healing. J Voice 2006; 20:(3) 443-451.
50. Tateya T, Tateya I, Bless DM. Immuno-scanning electron microscopy of collagen types I and III in human vocal fold lamina propria. Ann Otol Rhinol Laryngol. 2007;116:(2) 156-159.
51. Welham NV, Dailey SH, Ford CN, Bless DM. Voice handicap evaluation of patients with pathologic sulcus vocalis. Ann Otol Rhinol Laryngol 2007;116:(6) 411-417.
52. Yan YL, Damrose E, Bless D. Functional analysis of voice using simultaneous high-speed imaging and acoustic recordings. J Voice. 2007; 21:(5) 604-616.
53. Tateya T, Tateya I, Surles RL, Tanumihardjo S, Bless DM. Roles of vitamin A and macula flava in maintaining vocal folds. Ann Otol Rhinol Laryngol. 2008; 117:(1) 65-73.
54. Tateya I, Tateya T, Surles RL, Kanehira K, Tanurnihardjo S, Bless DM. Vitamin A deficiency causes metaplasia in vocal fold epithelium: A rat study. Ann Otol Rhinol Laryngol. 2008; 117:(2) 153-158
55. Welham NV, Lim X, Tateya I, Bless DM. Inflammatory factor profiles one hour following vocal fold injury. Ann Otol Rhinol Laryngol. 2008; 117:(2) 145-152.
56. Connor NP, Cohen SB, Theis SM, Thibeault SL, Heatley DG, Bless DM. Attitudes of children with dysphonia. J Voice. 2008; 22:(2) 197-209.
57. Lim XH, Bless DM, Munoz-Del-Rio A, Welham NV. Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblasts. Ann Otol Rhinol Laryngol. 2008;117:(3) 227-238.
57. XH, Bless DM, Munoz-Del-Rio A, Welham NV. Changes in cytokine signaling and extracellular matrix production induced by inflammatory factors in cultured vocal fold fibroblasts. Annals of Otology Rhinology and Laryngology 2008; 117(3) 227-238.
58. Connor NP, Cohen SB, Theis SM, Thibeault SL, Heatley DG, Bless DM. Attitudes of Children With Dysphonia. Journal of Voice, March 2008;22(2):197-209.
59. Welham NV, Marriott G, Tateya I, Bless DM. Proteomic changes in rat thyroarytenoid muscle induced by botulinum neurotoxin injection. Proteomics. 2008; 8:(9) 1933-1944.
60. Patel R, Dailey S, Bless D. Comparison of high-speed digital imaging with stroboscopy for laryngeal imaging of glottal disorders. Ann Otol Rhinol Laryngol 2008; 117:(6) 413-424.
61. Welham NV, Montequin DW, Tateya I, Tateya T, Choi SH, Bless DM., A rat excised larynx model of vocal fold scar. Journal of Speech, Language and Hearing Research (In Press).
62. Yamashita M, Bless DM, Welham NV. Surgical method to create vocal fold injuries in mice. Annals of Otology, Rhinoloy and Laryngology. 2009; 118:131-138.
63. Welham NV, Montequin DW, Tateya I, Tateya T, Choi SH, Bless DM. A rat excised larynx model of vocal fold scar. J Speech Lang Hear.Res 2009; 52:(4) 1008-1020.
C. Research Support.
NIH 2R01DC4428 (Bless, PI) 7/1/06-6/30/11
Characterization and Treatment of the Scarred Vocal Fold
The long-range aim of this project encompasses the characterization and treatment of the more universal phenomenon of vocal fold scarring. This will be accomplished by characterizing laryngeal scarring and its influence on phonation, both pre- and post-treatment using controlled laboratory experiments and computer modeling experiments.
R01 DC006019 (Jiang, PI) 4/1/03-3/31/09
Chaos in Human Phonation and Its Measurement
This proposal focuses on applying chaos theory to the study of normal and disordered phonation. Research will focus on the chaotic dynamics of the lumped-parameter model of vocal folds and finite element analysis (FEA), modeling of the asymmetry, vocal polyps, and dehydration with excised larynx, and analyzing nonlinear dynamic characteristics of data obtained from patients with vocal nodules and polyps, vocal fold paralysis, laryngeal carcinoma, and Parkinson’s disease
NIH, NIDCD 5R01DC005522 (Jiang, PI) 1/1/07-12/31/11
Physiology and Measurement of Vocal Fold Vibration $250,000
The long-range goals of this experimental work are to understand better both normal and pathological phonation and to contribute to the development of valid, comprehensive and noninvasive clinically feasible methods of representing and measuring the physiology of phonation.
NIH R01 (Jiang, PI) 7/1/07-6/1/11
Aerodynamic Study for Laryngeal Function $250,000
Assessment Using Airflow Interruption Methods
This proposal focuses on applying current aerodynamic theories and computerized instrumentation to improve methods of assessing laryngeal function.
NIH 1T32DC009401 - 01A1 (Bless, PI) 7/1/09-6/30/14
University of Wisconsin Voice Research Training Program
The overall long term goal of the UW Voice Research Training Program is to foster the development of translational research skills in future leaders in the field of voice science.
NIH, NIDCD (R01 DC4428-1)
Phonosurgical Optimization Criteria for Sulcus Vocalis 5/1/00-4/31/06
Role: Principal Investigator
This grant proposes to develop optimization criteria for phonosurgical treatment of scarring represented by sulcus vocalis. This will be accomplished through a unique mixture of 1) clinical and surgical trials, 2) histological and molecular studies, 3) laboratory experiments, and 4) computer modeling.
NIH, NIDCD (McMurray, PI) 1/1/04-12/31/06
1 R03 DC005917-01
Quantifying Effects of Treatment of Pediatric Dysphonia
P60 DC00976 (Titze)
NIH, NIDCD 10/1/95-8/31/00
National Center for Voice and Speech
Role: PI for University of Wisconsin project
NSF (Yan, Bless, Co-PIs) 7/1/04-6/30/07
Develop Analytical Tools for High Speed Laryngeal Imaging in Clinical Applications
Role: Co-Principal Investigator
NIH, NIDCD R03 DC4943-1 (Heatley, PI) 1/14/02 -12/31/06
Voice-Related Quality of Life in Dysphonic Children
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